A reader-funded review of treatments, supplements & cutting-edge wellness · Issue No. 14 · May 2026
The Comparison Desk

GLP-1 agonists,
side by side.

Four molecules, one rubric. We separate published outcomes, regulatory status, cost reality, and open questions so the comparison is useful rather than breathless.

Tirzepatide
GLP-1 / GIPA−

Tirzepatide

Mounjaro · Zepbound

Mean loss22.5%
Monthly cost$1,059
Semaglutide
GLP-1 / GIPA−

Semaglutide

Ozempic · Wegovy

Mean loss14.9%
Monthly cost$1,349
Liraglutide
GLP-1 / GIPB−

Liraglutide

Saxenda · Victoza

Mean loss7.6%
Monthly cost$1,440
Retatrutide
GLP-1 / GIPB+

Retatrutide

Investigational

Mean loss24.2%
Monthly costNot approved
№ 02

The full rubric

14 dimensions · Open methodology

Dimension
Tirzepatide
Semaglutide
Liraglutide
Retatrutide
Receptor activity
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
Mean weight loss
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
Cardiovascular outcomes
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
GI side effects
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
FDA status
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
Glow Verdict
Best-in-class
Conservative pick
Outclassed
Emerging / investigational