The Comparison Desk
GLP-1 agonists,
side by side.
Four molecules, one rubric. We separate published outcomes, regulatory status, cost reality, and open questions so the comparison is useful rather than breathless.

A−
Tirzepatide
Mean loss22.5%
Monthly cost$1,059

A−
Semaglutide
Mean loss14.9%
Monthly cost$1,349

B−
Liraglutide
Mean loss7.6%
Monthly cost$1,440

B+
Retatrutide
Mean loss24.2%
Monthly costNot approved
№ 02
The full rubric
14 dimensions · Open methodology
Dimension
Tirzepatide
Semaglutide
Liraglutide
Retatrutide
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
Best-in-class
Conservative pick
Outclassed
Emerging / investigational
Best-in-class
Conservative pick
Outclassed
Emerging / investigational